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Related Experiment Video

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The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers
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RNF186 as a prognostic biomarker and its correlation with immune cell infiltration in clear cell renal cell

Peng Wu1, Xiaolu Zhang1, Jia Zou2

  • 1Department of Oncology, Guangyuan Central Hospital, Guangyuan, China.

Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

Ring finger 186 (RNF186) is upregulated in clear cell renal cell carcinoma (ccRCC), acting as a positive prognostic biomarker. High RNF186 expression predicts better outcomes and enhances sensitivity to targeted therapies like sunitinib.

Keywords:
RNF186clear cell renal cell carcinoma (ccRCC)immune infiltrationprognosistargeted therapy

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • The role of Ring finger 186 (RNF186) in cancer development is recognized, but its specific function in clear cell renal cell carcinoma (ccRCC) is not well-defined.
  • Understanding RNF186's involvement is crucial for advancing ccRCC diagnostics and therapeutics.

Purpose of the Study:

  • To investigate the expression, diagnostic, and prognostic significance of RNF186 in clear cell renal cell carcinoma (ccRCC).
  • To explore RNF186's interactions, functional pathways, immune microenvironment associations, and potential as a therapeutic target in ccRCC.

Main Methods:

  • Analysis of RNF186 expression using TCGA, GEO, and clinical ccRCC samples.
  • Evaluation of diagnostic and prognostic value, protein interactions, pathway enrichment, immune microenvironment, and drug sensitivity.
  • Inclusion of single-cell analysis and molecular docking studies.

Main Results:

  • RNF186 was significantly upregulated in ccRCC and inversely correlated with tumor stage.
  • High RNF186 expression correlated with improved prognosis and demonstrated diagnostic utility.
  • RNF186 is involved in key biological processes and immune modulation, particularly within malignant cells, and predicts enhanced sensitivity to sunitinib.

Conclusions:

  • RNF186 is a potential biomarker for prognosis prediction in ccRCC.
  • RNF186 aids in characterizing the ccRCC tumor microenvironment.
  • RNF186 may guide personalized targeted therapy selection in ccRCC.