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Updated: Jan 7, 2026

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Oncology-Derived Strategies for Age-Related Diseases: Intersections of Oncogenesis, Senescence, and Immunity

Hao Li1,2, Jingzeng Wang1,2, Chao Liu1,2

  • 1Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

Aging and Disease
|December 26, 2025
PubMed

Insights

Cancer and aging share biological pathways. Therapies targeting cancer, like senolytics and immunotherapies, may also combat aging by restoring immune function and mitigating cellular damage.

Area of Science:

  • Oncology
  • Gerontology
  • Immunology

Background:

  • Shared molecular pathways link cancer development (oncogenesis) and the aging process.
  • Cellular surveillance and response mechanisms are crucial for both cancer prevention and healthy aging.

Purpose of the Study:

  • To review overlapping molecular pathways in cancer and aging.
  • To explore how cancer therapies can be repurposed for age-related diseases.
  • To highlight immune restoration as a therapeutic strategy for aging.

Main Methods:

  • Literature review of recent developments in oncology, gerontology, and immunology.
  • Analysis of shared biological pathways and therapeutic strategies.
  • Examination of immune system dynamics in aging and cancer.

Main Results:

  • Senolytic agents, metabolic modulators, and immunotherapies show potential for both cancer treatment and mitigating aging.
  • Cancer therapies may be adapted to manage age-related conditions, with immune restoration being a key mechanism.
  • Understanding immune system changes is critical for effective therapeutic adaptation.

Conclusions:

  • Targeting shared pathways offers a dual approach to treating cancer and age-related diseases.
  • Repurposing cancer therapies requires careful consideration of potential benefits and risks.
  • Immune restoration is a promising strategy for improving healthspan and treating age-related conditions.

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