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Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Agnieszka Kulczynska-Przybik1, Daria Krawczuk1, Renata Borawska1

  • 1Department of Neurodegeneration Diagnostics, Medical University of Bialystok, Bialystok, Poland.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

Chemokine CXCL1 is elevated in Alzheimer's disease (AD) patients' cerebrospinal fluid and correlates with tau pathology markers. This suggests CXCL1 may contribute to AD pathogenesis and tau protein mechanisms.

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Area of Science:

  • Neuroscience
  • Immunology
  • Biochemistry

Background:

  • Alzheimer's disease (AD) pathogenesis involves complex mechanisms, including the role of chemokine CXCL1.
  • CXCL1 is implicated in monocyte migration to the brain and tau protein cleavage in AD.
  • CXCL1 may activate neuronal receptors, leading to tau hyperphosphorylation in pathological conditions.

Purpose of the Study:

  • To investigate CXCL1 levels in cerebrospinal fluid (CSF) of AD patients and compare them with cognitively normal subjects.
  • To examine the association between CSF CXCL1 levels and established biomarkers of tau protein pathology in AD.

Main Methods:

  • Multiplexing, SIMOA, and ELISA techniques were used to measure CXCL1 concentrations.
  • Neurochemical dementia biomarkers were quantified in CSF and plasma samples.
  • Patient groups included those with AD and cognitively normal individuals.

Main Results:

  • CSF CXCL1 concentrations were significantly higher in AD patients compared to controls.
  • CSF CXCL1 levels showed a significant correlation with CSF pTau181 protein in AD patients.
  • A significant association was found between CSF CXCL1 and plasma Tau protein levels in AD.

Conclusions:

  • CXCL1 appears to play a role in the pathogenesis of Alzheimer's disease.
  • CXCL1 may be particularly involved in the mechanisms driving tau protein pathology in AD.