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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Ran An1

  • 1Peking University, Beijing, China.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

Cognitive function significantly impacts gait, especially temporal components, in older adults. Gait speed decline can indicate cognitive impairment, with temporal gait features being key prognostic indicators.

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Area of Science:

  • Gerontology
  • Neuroscience
  • Biomechanics

Background:

  • Gait performance decline is common in older adults with cognitive impairment.
  • The specific influence of cognitive function on gait, beyond aging, requires further investigation.
  • Understanding this relationship is crucial for identifying early markers of cognitive decline.

Purpose of the Study:

  • To examine age-related gait trajectories across the dementia spectrum.
  • To determine the mediating role of cognitive function in the aging-gait relationship.
  • To identify gait features as potential biomarkers for cognitive impairment.

Main Methods:

  • Observational cohort study in China (2022) with 289 participants (cognitively normal, subjective cognitive decline, cognitive impairment).
  • Neuropsychological and gait assessments (spatial, temporal, spatio-temporal parameters) under single- and dual-task conditions using computer vision.
  • Polynomial regression for age-related gait trajectories and structural equation modeling for mediation analysis.

Main Results:

  • Significant differences in stride speed observed across cognitive groups under both single- and dual-task conditions.
  • Spatial and spatio-temporal gait declined with age; temporal gait parameters increased with age in subjective cognitive decline and cognitive impairment groups.
  • Cognitive function partially mediated age effects on spatial/spatio-temporal gait and fully mediated effects on temporal gait.

Conclusions:

  • Spatial and spatio-temporal gait are mainly influenced by normal aging.
  • Temporal gait components are more sensitive to cognitive function decline.
  • Gait speed, particularly temporal components, shows potential as a non-cognitive biomarker for cognitive decline.