Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

749
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
749
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

516
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
516

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ruthenium(II)-catalyzed regioselective C8-H acyloxylation of indolizines with carboxylic acids.

Chemical communications (Cambridge, England)·2026
Same author

Virtual reality in planning complex heart surgery.

The Journal of thoracic and cardiovascular surgery·2026
Same author

Bioinspired zein-chitosan nanocomplexes for co-delivery of 5-fluorouracil and silibinin: Optimization, characterization and anticancer activity in colorectal cancer.

International journal of biological macromolecules·2026
Same author

Design of Multi-Epitope DIVA-Compatible Vaccine Candidate Against Canine Parvovirus 2.

Journal of molecular recognition : JMR·2026
Same author

"Migrant" Ductal Tissue in the Aortic Arch: A Substrate for Prostaglandin-Responsive Coarctation.

JACC. Case reports·2026
Same author

Wnt signaling promotes inflammation and EMT-associated gene expression in mesenchymal TNBC.

Scientific reports·2026
Same journal

Evidence for progressive neurodegeneration in iatrogenic cerebral amyloid angiopathy.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Human brain connectome profiles mediate the relationship between pathology burden and clinical phenotypes in Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Kat5 cKO mouse replicates biological domain signatures associated with Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Evaluation of CSF and plasma tau species as fluid surrogate candidates for tau PET in prodromal to moderate Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Associations of self-reported obstructive sleep apnea with cognition and dementia risk in cognitively unimpaired middle-aged adults.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Inflammation profiles in Alzheimer's disease relate to cognition and neurodegeneration.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
See all related articles

Related Experiment Video

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K

Biomarkers.

Shampa Ghosh1, Krishna Kumar Singh2, Amit Kumar Pandey3

  • 1GloNeuro Academy, Noida, Uttar Pradesh, India.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

Mitochondrial dysfunction is a key factor in aging and neurodegenerative diseases like Alzheimer's and Parkinson's. Understanding these pathways is crucial for developing new therapies to protect brain health.

More Related Videos

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

702

Related Experiment Videos

Last Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K
Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

702

Area of Science:

  • Neuroscience
  • Cell Biology
  • Gerontology

Background:

  • Mitochondrial dysfunction is central to aging and neurodegenerative diseases.
  • Understanding its mechanisms is vital for developing effective therapeutic strategies.
  • This review explores pathways of mitochondrial dysfunction in aging and neurodegeneration for potential intervention targets.

Purpose of the Study:

  • To elucidate the mechanisms connecting mitochondrial dysfunction with aging and neurodegenerative diseases.
  • To identify potential therapeutic targets for intervention.
  • To synthesize current knowledge on mitochondrial dysfunction in aging and neurodegeneration.

Main Methods:

  • Comprehensive literature review.
  • Synthesis of current knowledge on mitochondrial dysfunction.
  • Focus on key cellular and molecular pathways including structure, function, energy metabolism, and homeostasis.

Main Results:

  • Aging mitochondria show reduced effectiveness, decreased ATP, impaired oxidative phosphorylation, and increased reactive oxygen species.
  • Neurodegenerative diseases (Alzheimer's, Parkinson's, Huntington's) exhibit specific mitochondrial abnormalities like deficient mitophagy and mtDNA mutations.
  • These mitochondrial issues contribute to neuronal cell death and disease progression.

Conclusions:

  • Diverse mechanisms link mitochondrial dysfunction to aging and neurodegeneration.
  • Identified pathways are critical for therapeutic intervention to preserve mitochondrial integrity.
  • Further research into these pathways may yield novel treatments for age-related and neurodegenerative conditions.