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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
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Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Related Experiment Video

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Oladotun V Olalusi1,2,3, Tolulope O Akinyemi4, Andrea L Benedet5

  • 1Neuroscience and ageing research unit, Institute of Advanced Medical Research and Training (IAMRAT), College of Medicine, University of Ibadan, Ibadan Nigeria, Oyo, Nigeria.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

Hand grip strength is linked to neurodegeneration markers in older Nigerians. This physical measure may help screen for Alzheimer's Disease risk alongside other biomarkers.

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Area of Science:

  • Neuroscience
  • Gerontology
  • Biomarker Discovery

Background:

  • Plasma biomarkers and physical frailty measures aid cognitive screening and diagnosis.
  • Hand grip strength (HGS) indicates physical health and cognitive decline.
  • The link between HGS and Alzheimer's Disease (AD) plasma biomarkers is unknown.

Purpose of the Study:

  • To investigate the association between HGS and plasma biomarkers of AD and neurodegeneration.
  • To explore HGS as a potential non-invasive screening tool for cognitive impairment.

Main Methods:

  • Longitudinal community-based cohort study (VALIANT) in Nigeria.
  • Recruited 1036 older adults, assessed cognitive function, and measured plasma biomarkers (GFAP, NfL, p-tau217, Aβ42/40).
  • Used multiple linear regression to analyze the relationship between HGS and plasma biomarkers, adjusting for covariates.

Main Results:

  • HGS showed an independent relationship with plasma p-tau217, Aβ42/40, and NfL.
  • Significant associations were found between HGS and all measured plasma biomarkers in regression analyses.

Conclusions:

  • Hand grip strength is independently associated with plasma markers of neurodegeneration in older Nigerian adults.
  • HGS and plasma biomarkers may serve as complementary screening tools for identifying individuals at risk for AD and related dementias (AD/ADRD).