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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
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Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Related Experiment Video

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Petrice M Cogswell1, Gregory M Preboske2, Gregory Klein3

  • 1Mayo Clinic, Rochester, MN, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

Some amyloid-related imaging abnormality-H microhemorrhages may resolve, challenging the belief they are permanent. This finding impacts managing Alzheimer's disease immunotherapy by showing ARIA-H's dynamic nature.

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Area of Science:

  • Neurology
  • Radiology
  • Immunotherapy

Background:

  • Amyloid-Related Imaging Abnormalities (ARIA) are adverse events in Alzheimer's disease anti-amyloid immunotherapies.
  • ARIA presents as edema/effusion (ARIA-E) or microhemorrhages/siderosis (ARIA-H).
  • ARIA-H is conventionally considered permanent hemosiderin staining.

Purpose of the Study:

  • To investigate the potential resolution of ARIA-H microhemorrhages.
  • To challenge the established understanding of ARIA-H permanence.

Main Methods:

  • Retrospective analysis of MRI scans from gantenerumab Alzheimer's disease trials.
  • Co-registration and neuroradiologist review of serial T2* GRE MRI sequences.
  • Tracking of individual microhemorrhages to define resolution criteria.

Main Results:

  • 12 patients met inclusion criteria; 5 (41%) showed resolved microhemorrhages.
  • Microhemorrhage resolution occurred over 10-40 months post-ARIA-E.
  • Resolved microhemorrhages were clustered regionally with ARIA-E.

Conclusions:

  • Some ARIA-H microhemorrhages can resolve, contrary to current understanding.
  • Microhemorrhage resolution is relevant for managing anti-amyloid immunotherapies.
  • ARIA-H may exhibit a dynamic nature, not solely permanent staining.