Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

749
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
749
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

516
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
516

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

SVIP in plasma: a candidate blood-based biomarker for early detection of amnestic mild cognitive impairment.

Frontiers in aging neuroscience·2026
Same author

Multimetric brain functional-structural connectivity mutual coupling for mild cognitive impairment identification.

Neural networks : the official journal of the International Neural Network Society·2026
Same author

Hepatic Vessel Map (HVM): An Expert-Annotated CT Dataset for Clinically Applicable AI in Liver Vascular Segmentation and Surgical Planning.

Scientific data·2026
Same author

Development and validation of an MRI-based deep learning system for triple-class ER expression classification in breast cancer: a large-scale multicenter study.

BMC medicine·2026
Same author

Elevated plasma klotho levels attenuate Alzheimer's disease pathologies and cognitive decline in APOE ε4 carriers.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

The role of radiological imaging in differentiating malignant and benign pulmonary nodules: a retrospective study.

BMC medical imaging·2026
Same journal

Multimorbidity burden and patterns associated with DeepBrainNet-derived brain-age gap in dementia-free older adults: A community-based study.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Reply to "Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities".

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Correlates and predictors of self-efficacy among dementia caregivers: D-CARE findings.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

What should convince a clinician of disease modification in Alzheimer's disease clinical trials?

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Primary cilia-extracellular vesicle crosstalk in Alzheimer's disease: Emerging mechanisms and biomarker potential.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
See all related articles

Related Experiment Video

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K

Biomarkers.

Xiang Fan1, Xiqian Zhang2, Keyan Yu1

  • 1Peking University Shenzhen Hospital, Shenzhen, Guangdong, China.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

A new DTI-ALPS mapping method reveals whole-brain glymphatic system changes in cognitive impairment. This voxel-based approach offers a comprehensive assessment of glymphatic activity and its association with cognitive decline and white matter hyperintensities.

More Related Videos

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

702

Related Experiment Videos

Last Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

37.1K
Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.9K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

702

Area of Science:

  • Neuroimaging
  • Neurology
  • Biomedical Engineering

Background:

  • The glymphatic system plays a crucial role in dementia pathogenesis.
  • Conventional diffusion tensor image analysis along the perivascular space (DTI-ALPS) using regions of interest (ROIs) is a current assessment method.
  • Limitations exist in the conventional ROI-based DTI-ALPS method for comprehensive glymphatic system evaluation.

Purpose of the Study:

  • To introduce a novel voxel-based method, DTI-ALPS mapping, for analyzing whole cerebral white matter DTI-ALPS.
  • To characterize DTI-ALPS pattern changes in cognitive impairment using the new mapping technique.
  • To provide a full-scale, voxel-based approach for assessing glymphatic system activity.

Main Methods:

  • Included 304 participants (182 cognitively unimpaired, 93 mild cognitive impairment, 29 dementia) from the STAR Cohort.
  • Utilized 3.0T MRI scans (3D T1-weighted and DTI sequences).
  • Applied DTI-ALPS mapping to visualize white matter fibers across 30 regions, comparing it with the conventional ROI-based method and analyzing correlations with cognitive scores (MMSE, MoCA) and white matter hyperintensities (WMH).

Main Results:

  • DTI-ALPS mapping revealed whole cerebral white matter ALPS patterns, with significant differences in 13 out of 30 regions between groups.
  • The mapping showed significant positive correlations with MoCA (26/30 regions) and MMSE (11/30 regions).
  • A significant negative correlation was observed between DTI-ALPS mapping and WMH in 26 out of 30 regions.

Conclusions:

  • DTI-ALPS mapping offers a robust, intuitive, and comprehensive method for evaluating glymphatic system changes.
  • This voxel-based approach overcomes limitations of conventional ROI-based methods.
  • DTI-ALPS mapping effectively reveals changing patterns of the glymphatic system associated with cognition and white matter hyperintensities.