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Prevalence and Risk Factors for Hepatitis C Virus Infection in Vulnerable Populations in Romania: A Population-based
Anca Trifan1, Laura Huiban2, Mihaela Moscalu3
1Department of Gastroenterology, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, Iasi, Romania. ancatrifan@yahoo.com.
Journal of Gastrointestinal and Liver Diseases : JGLD
|December 26, 2025
Summary
Hepatitis C virus (HCV) infection prevalence in Romania is 1.21%. Key risk factors identified include older age, male gender, and specific medical histories, informing national elimination strategies.
Area of Science:
- * Hepatology and Virology
- * Public Health and Epidemiology
Background:
- * Viral hepatitis C (HCV) is a significant global health concern, causing cirrhosis and hepatocarcinoma.
- * HCV infection contributes to substantial worldwide morbidity and mortality.
- * Romania faces a considerable public health challenge due to HCV.
Purpose of the Study:
- * To determine the prevalence of Hepatitis C Virus (HCV) infection in Romania.
- * To identify significant risk factors associated with HCV transmission within the Romanian population.
Main Methods:
- * A prospective national screening program (LIVE(RO)2) conducted from 2021 to 2023.
- * Involved 320,000 participants, with a focus on vulnerable populations.
- * Data collection included questionnaires on potential HCV transmission risk factors.
Main Results:
- * Identified an HCV prevalence of 1.21% (3,859 individuals) among 320,000 screened participants.
- * HCV-infected individuals were significantly older (mean age 65.8 years) than uninfected participants (mean age 54.03 years).
- * Key risk factors included male gender, age groups 30-49 and 60-69, low education, history of transfusions, hemodialysis, surgeries, tattooing, and unprotected sexual contact.
Conclusions:
- * The study confirms a 1.21% prevalence of HCV infection in Romania.
- * Findings provide crucial data for Romania's national HCV elimination goals.
- * Highlights the need for targeted healthcare support for vulnerable populations.
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