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Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Klodian Dhana1, Konstantinos Arfanakis1,2,3, Neelum T Aggarwal1,4

  • 1Rush University Medical Center, Chicago, IL, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

The Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet may help slow Alzheimer's disease pathology. A 3-year study found the MIND diet maintained plasma amyloid-beta 42/40 levels, unlike the control group which showed a decline.

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Area of Science:

  • Neuroscience
  • Nutritional Science
  • Gerontology

Background:

  • Plasma amyloid-beta (Abeta) levels, particularly the Abeta42/40 ratio, are indicators of brain amyloid pathology and Alzheimer's disease and related dementias (ADRD) risk.
  • A lower plasma Abeta42/40 ratio is associated with an increased risk of ADRD.

Purpose of the Study:

  • To investigate the impact of the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet on longitudinal changes in plasma Abeta42/40 levels.
  • To determine if the MIND diet can influence biomarkers associated with Alzheimer's disease pathology.

Main Methods:

  • A 3-year randomized controlled trial involving 604 participants aged 65-85 with a family history of dementia.
  • Participants were assigned to either the MIND diet, emphasizing brain-healthy foods, or a control diet, with both promoting weight loss.
  • Longitudinal changes in plasma Abeta42/40 levels were analyzed using multivariable-adjusted linear mixed-effect models.

Main Results:

  • Plasma Abeta42/40 levels remained statistically unchanged in the MIND diet group over 3 years.
  • In contrast, the control group experienced an average decline of 2.8% in plasma Abeta42/40 levels (p=0.024).
  • Baseline plasma Abeta42/40 levels were similar between the MIND diet and control groups.

Conclusions:

  • Dietary intervention significantly influences longitudinal changes in plasma Abeta42/40 levels.
  • The MIND diet may mitigate declines in plasma Abeta42/40, suggesting a potential to reduce Alzheimer's disease brain pathology.
  • The findings indicate the MIND diet could potentially lower the risk of developing Alzheimer's disease and related dementias.