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Related Concept Videos

Special considerations while measuring oxygen saturation01:19

Special considerations while measuring oxygen saturation

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Assessing respiratory rate concurrently with pulse measurement is fundamental to patient care, providing valuable insights into the patient's respiratory function. The normal breathing rate for an adult usually falls within a normal range of 12 to 20 breaths per minute. Abnormal respiratory rates can signal underlying health conditions or the need for immediate intervention.
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Radiological Investigation II: MRI and Ventilation Perfusion Scan01:30

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Description
Magnetic Resonance Imaging (MRI) and Ventilation Perfusion Scans are two radiological investigations that offer detailed diagnostic images of the body, particularly lung structures.
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MRI uses magnetic fields and radiofrequency signals to distinguish between normal and abnormal tissues. This technology provides a more detailed diagnostic image than CT scans, enabling it to characterize pulmonary nodules, stage bronchogenic carcinoma, and evaluate inflammatory activity in...
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Related Experiment Video

Updated: Jan 7, 2026

Quantitative Mapping of Specific Ventilation in the Human Lung using Proton Magnetic Resonance Imaging and Oxygen as a Contrast Agent
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Partial volume correction for quantifying venous oxygen saturation levels using contrast-enhanced MRI.

Sagar Buch1, Yifan Lv2, Mingming Wang2

  • 1Department of Neurology, Wayne State University, Detroit, MI, USA.

Neuroimage
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

This study developed a new MRI method to accurately measure brain oxygenation in small veins, improving diagnosis for conditions like stroke. The technique corrects for errors, providing more reliable results for venous oxygen saturation (Yv) and oxygen extraction fraction (OEF).

Keywords:
Contrast-enhanced MRIQuantitative neuroimagingQuantitative susceptibility mappingStrokeVenous oxygen saturation

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Last Updated: Jan 7, 2026

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Area of Science:

  • Neuroimaging
  • Medical Physics
  • Vascular Biology

Background:

  • Accurate brain oxygenation quantification is vital for neurological disease management, particularly stroke.
  • Quantitative Susceptibility Mapping (QSM) measures venous oxygen saturation (Yv) but suffers from partial volume effects (PVEs) in small vessels.
  • PVEs in QSM lead to inaccurate Yv and oxygen extraction fraction (OEF) measurements, hindering clinical application.

Purpose of the Study:

  • To develop and validate a robust method for mitigating PVEs in QSM-derived Yv and OEF measurements.
  • To improve the accuracy of assessing cerebral hemodynamics in small cerebral veins using MRI.
  • To enhance the clinical utility of QSM for diagnosing and managing neurological conditions.

Main Methods:

  • Integration of QSM with high-resolution, contrast-enhanced T1-weighted imaging to generate regional cerebral blood volume (rCBV) maps.
  • Utilizing rCBV maps to correct for PVEs in QSM data acquired from 30 stroke patients.
  • Comparison of corrected versus uncorrected QSM data to assess the impact on venous susceptibility (Δχ) and Yv.

Main Results:

  • Corrected QSM images showed a significant increase in venous susceptibility (Δχ) values (441.46 ± 61.14 ppb vs. 163.26 ± 19.66 ppb; p<0.001).
  • The method yielded a physiologically plausible mean Yv of 70.42 ± 4.09%.
  • Improved distinction of asymmetrically prominent cortical veins (APCVs) with lower Yv values observed in some cases, indicating reduced oxygenation.

Conclusions:

  • Contrast-enhanced rCBV mapping effectively corrects PVEs in QSM for small cerebral veins.
  • This approach provides more reliable measurements of Yv and OEF, crucial for clinical insights.
  • The validated method enhances the assessment of cerebral hemodynamics in stroke patients and other neurological conditions.