Baseline Haemodynamic Measurements and Immediate Change in Parameters after Revascularisation: Ankle Pressure, Ankle...

To assess the baseline haemodynamic parameters in Best Endovascular Therapy versus Best Surgical Therapy in Patients with CLTI (BEST-CLI) trial patients and to analyse the change after revascularisation (ClinicalTrials.gov identifier: NCT02060630).

Baseline and 30 day post-operative assessment parameters included ankle brachial index (ABI), toe pressure (TP), and toe brachial index. Statistical analyses were performed according to the actual treatment received and carried out separately in each cohort.

Cohort 1 included patients who had a single segment of great saphenous vein available. At baseline, median ABI was 0.51 (interquartile range [IQR] 0.38, 0.68) and median TP was 33 mmHg (IQR 28.5, 48 mmHg), with no statistically significant differences between the surgical and endovascular groups. The median ABI increase was 0.44 (IQR 0.25, 0.60) in the bypass group and 0.44 (IQR 0.25, 0.61) in the endovascular group (p = .55). The median TP increase in the surgical group was 40 mmHg (IQR 13, 60 mmHg), compared with 29 mmHg (IQR 9, 54 mmHg) in the endovascular group (p = .032). An ABI increase of > 0.30 and or a TP increase of > 30 mmHg was noted in 92.4% and 90.1% of the patients in the surgical and endovascular groups, respectively (p = .33). Cohort 2 included patients who needed an alternative bypass conduit. The median ABI increase in the surgical and endovascular groups was 0.40 and 0.52 (p = .50), respectively. The median TP increase in the surgical group was 36 mmHg (IQR 7, 65 mmHg), compared with 47 mmHg (IQR 22, 65 mmHg) in the endovascular group (p = .27). An ABI increase of > 0.30 and or a TP increase of > 30 mmHg was noted in 91.0% and 90.7% of the patients in the surgical and endovascular groups, respectively (p = .94).

In patients for whom a comparison was available, > 90% had statistically significantly improved haemodynamic values 30 days after revascularisation. A greater increase in TP was noted with surgical bypass than with endovascular revascularisation among patients who had a single segment great saphenous vein available.