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Culture Methods to Determine the Limit of Detection and Survival in Transport Media of Campylobacter Jejuni in Human Fecal Specimens
Published on: March 10, 2020
Post-infectious Guillain-Barré syndrome during a cholera outbreak in Yemen: A pediatric case with confirmed
Abdullah Nasser1, Maryam Salem Awadh Bagnaf2, Faten Awadh Abdullah Salem2
1Medipan GmbH, GA Generic Assays GmbH, Dahlewit, Germany; Assr Medical Technology, International research collaboration, Riyadh, Saudi Arabia.
Insights
A pediatric case of Guillain-Barré syndrome (GBS) occurred after Campylobacter jejuni infection during a cholera outbreak in Yemen. This highlights challenges in diagnosing post-infectious autoimmune conditions in low-resource settings.
Area of Science:
- Neurology
- Infectious Diseases
- Immunology
Background:
- Yemen faces overlapping epidemics of infectious diseases like cholera and under-recognized post-infectious autoimmune conditions due to conflict and a fragile healthcare system.
- Campylobacter jejuni is a known trigger for Guillain-Barré syndrome (GBS), an autoimmune disorder affecting peripheral nerves.
Abstract:
Yemen's prolonged conflict and fragile healthcare infrastructure have created a setting where infectious diseases like cholera frequently overlap with under-recognized post-infectious autoimmune conditions. In this context, we report a pediatric case of Guillain-Barré syndrome (GBS) following recent Campylobacter jejuni infection during a laboratory-confirmed cholera outbreak in rural Southern Yemen. The 12-year-old patient presented with acute flaccid paralysis and respiratory failure after a diarrheal illness consistent with cholera. Nerve conduction studies supported the GBS diagnosis, and advanced serological testing confirmed prior C. jejuni exposure with strong anti-GD1b IgG positivity. The case underscores the role of molecular mimicry in GBS pathogenesis, diagnostic challenges in low-resource settings, and the importance of international collaboration in confirming immune-mediated neurological diseases during simultaneous epidemics.
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