Sublethal fipronil exposure impairs development and behavior in Drosophila melanogaster
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View abstract on PubMed
Summary
This summary is machine-generated.Fipronil insecticide significantly impacts fruit fly development, reducing survival and impairing behavior. This study highlights fipronil toxicity in Drosophila melanogaster, offering insights into invertebrate pesticide effects.
Area Of Science
- Environmental toxicology
- Developmental biology
- Insect toxicology
Background
- Pesticides, especially insecticides like fipronil, are crucial in agriculture.
- Fipronil, a phenylpyrazole insecticide, is recognized for its high toxicity.
- Understanding fipronil's effects on non-target organisms is vital.
Purpose Of The Study
- To investigate the morphometric and toxicological impacts of fipronil on Drosophila melanogaster development.
- To assess fipronil's effects across various concentrations on fly survival, emergence, and behavior.
- To analyze sex-dependent toxicological responses and morphological changes induced by fipronil.
Main Methods
- Oral exposure of Drosophila melanogaster embryos to a range of fipronil concentrations (16–490 nM).
- Monitoring of adult emergence, survival rates, and locomotor behavior.
- Application of canonical variate analysis (CVA) to detect sex-dependent morphometric differences.
Main Results
- Reduced adult emergence and survival decline at higher fipronil concentrations (≥327 nM).
- Impaired locomotor behavior observed at 81 nM in both male and female flies.
- Significant sex-dependent morphometric changes detected at lower concentrations (16 and 40 nM).
- Median lethal concentration (LC50) for 24-h mortality in adult flies was determined to be 442 nM.
Conclusions
- Fipronil exhibits significant toxicity to Drosophila melanogaster, affecting development, survival, and behavior.
- The study demonstrates sex-specific responses to fipronil exposure.
- Drosophila melanogaster serves as a valuable model for predicting fipronil's impact on other invertebrate species.
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