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GNA15 as a potential prognostic and immunological biomarker in ccRCC based on bioinformatics analysis and

Xiumin Xu¹, Zeping Zuo², Jinhai Zhu²

¹Department of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230601, China; Department of Urology, Tongling People's Hospital, Tongling, Anhui, 244000, China.

Experimental Cell Research

|December 26, 2025

Summary

GNA15 is highly expressed in clear cell renal cell carcinoma (ccRCC), promoting tumor growth and immune suppression. Targeting GNA15 may offer a new therapeutic strategy for this aggressive kidney cancer.

Keywords:

Cancer stemness GNA15 Immunotherapy Tumor microenvironment ccRCC

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Area of Science:

Oncology
Molecular Biology
Immunology

Background:

Clear cell renal cell carcinoma (ccRCC) is an aggressive kidney cancer subtype with limited treatment options.
The role of GNA15, a G protein alpha subunit, in ccRCC progression is not well understood.

Purpose of the Study:

To investigate the expression, function, and clinical significance of GNA15 in ccRCC.
To explore GNA15 as a potential prognostic biomarker and therapeutic target for ccRCC.

Main Methods:

Analysis of public datasets for GNA15 expression and correlation with clinical data.
Validation of GNA15 levels in ccRCC tissues and cell lines using immunofluorescence and western blotting.
Functional assays (e.g., migration, proliferation) and gene set enrichment analysis (GSEA) after GNA15 knockdown.

Main Results:

GNA15 is upregulated in ccRCC and associated with poor prognosis, advanced stage, tumor heterogeneity, and stemness.
High GNA15 expression correlates with an immunosuppressive microenvironment, including M2 macrophage and neutrophil infiltration.
GNA15 knockdown inhibits ccRCC cell proliferation, migration, and stemness marker expression, and reduces PD-L1 levels.

Conclusions:

GNA15 is a novel oncogenic factor and immune modulator contributing to ccRCC progression.
GNA15 represents a promising prognostic biomarker and therapeutic target for ccRCC.