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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Emily N Holy1, Guobao Wang1, Benjamin A Spencer1

  • 1University of California Davis, Davis, CA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

Alzheimer's disease (AD) amyloid-beta (Aβ) is detectable in the liver using total-body PET imaging. Increased liver Aβ signal in AD patients suggests the liver as a potential biomarker for disease progression.

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Area of Science:

  • Neuroscience
  • Medical Imaging
  • Biochemistry

Background:

  • Alzheimer's disease (AD) is characterized by amyloid-beta (Aβ) plaques in the brain.
  • Aβ is also present and degraded in peripheral organs like the liver.
  • Current PET imaging for AD is limited to the brain, overlooking systemic Aβ distribution.

Purpose of the Study:

  • To utilize total-body PET imaging to characterize liver Aβ signal over time.
  • To investigate differences in liver Aβ deposition between individuals with and without AD.
  • To establish optimal imaging windows for liver Aβ detection.

Main Methods:

  • 18F-florbetaben dynamic PET imaging was performed on the total-body uEXPLORER PET system.
  • Regions of interest were defined in eight liver segments and a composite liver region.
  • Standardized Uptake Value Ratio (SUVR) time-activity curves were analyzed using linear mixed effects models.

Main Results:

  • Individuals with AD (Aβ+) showed significantly increased liver SUVR compared to controls (Aβ-) at later time points (90-110 min).
  • Discrimination between Aβ+ and Aβ- groups was most significant at later time points.
  • Early and middle time points showed limited discrimination in liver SUVR.

Conclusions:

  • The liver exhibits an amyloid signal that changes over time, similar to the brain.
  • The 90-110 minute time window is optimal for evaluating liver amyloid burden using PET.
  • These findings support the liver as a potential peripheral biomarker for AD and systemic molecular processes.