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Related Concept Videos

Clinical Trials01:16

Clinical Trials

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Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
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Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

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Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
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Clinical Trials: Overview01:11

Clinical Trials: Overview

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Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
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Hypertension V: Nursing Management01:23

Hypertension V: Nursing Management

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The nursing management of hypertension involves accurately assessing symptoms, making a comprehensive nursing diagnosis, collaborating with patients to set goals, and implementing targeted interventions to mitigate the condition's impact and improve patient well-being.Comprehensive AssessmentThe initial step in nursing care for hypertension involves a thorough patient assessment. It includes evaluating symptoms such as headaches, dizziness, blurred vision, and previous hypertension episodes.
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Pre-Procedural Guidelines for Assessing Blood Pressure01:10

Pre-Procedural Guidelines for Assessing Blood Pressure

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Accurate blood pressure assessment is crucial for diagnosing and managing various health conditions. To ensure the reliability of these measurements, healthcare professionals must adhere to standardized pre-procedural guidelines. These guidelines enhance patient safety and improve the overall quality of healthcare. The following steps are essential for obtaining accurate and consistent blood pressure readings, from using the appropriate tools to ensuring effective communication with the...
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Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers01:26

Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers

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Receptor tyrosine kinase inhibitors (TKIs) and calcium channel blockers (CCBs) are two critical categories of drugs employed in the treatment of pulmonary artery hypertension (PAH). PAH is a disease that causes high blood pressure in the pulmonary arteries, resulting in chest pain, fatigue, and shortness of breath.
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...
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Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
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Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

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Preeclampsia trials that changed practice.

Eniola R Ibirogba1, Jennifer Grasch1, Maged M Costantine1

  • 1Division of Maternal-Fetal Medicine, Department of Obstetrics & Gynecology, The Ohio State University, United States.

Seminars in Perinatology
|December 26, 2025
PubMed
Summary
This summary is machine-generated.

Preeclampsia significantly harms mothers and newborns. This review highlights aspirin, statins, and hypertension treatment as key prevention and management strategies for preeclampsia.

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Area of Science:

  • Obstetrics and Gynecology
  • Maternal-Fetal Medicine
  • Cardiovascular Research

Background:

  • Hypertensive disorders of pregnancy, particularly preeclampsia, are leading causes of adverse maternal, fetal, and neonatal outcomes.
  • Effective prevention and management strategies are crucial to mitigate these risks.

Purpose of the Study:

  • To review pivotal clinical and translational studies that have informed the prevention and treatment of preeclampsia.
  • To synthesize current evidence on management strategies and identify areas for future research.

Main Methods:

  • Comprehensive literature review of clinical and translational studies.
  • Analysis of preclinical trials, randomized controlled trials, and clinical studies.
  • Synthesis of evidence on pharmacological interventions and delivery timing.

Main Results:

  • Low-dose aspirin is a standard prevention strategy; statins show emerging potential.
  • Treatment of mild chronic hypertension reduces preeclampsia risk and complications.
  • Magnesium sulfate for seizure prophylaxis and optimal delivery timing are defined evidence-based management aspects.

Conclusions:

  • Current research has established foundational prevention and treatment strategies for preeclampsia.
  • Further investigation into novel therapeutic targets and refined management is essential to reduce the persistent burden of preeclampsia.