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Updated: Jan 7, 2026

Understanding the Changes in Mitochondrial Morphology through Dynamic and Three-dimensional Fluorescence Micrographs
Published on: August 15, 2025
From Cellular Architecture to Regulation of Mitochondrial Function: Role of Vimentin in Ensuring Cellular Mitostasis
Roaa Deeb1,2, Anton S Shakhov1,3, Aleksandra S Churkina1,3
1Institute of Protein Research, Russian Academy of Sciences, Moscow, 119334, Russia.
Abstract:
Mitochondria play a central role in cell physiology, and in addition to performing their primary function as an energy source, they are involved in processes such as regulating intracellular calcium levels, generating reactive oxygen species, synthesizing many critical compounds, regulating apoptosis, and more. In this regard, maintaining them in a normal state is of great importance, ensuring their transport, intracellular distribution, timely biogenesis, and removal of damaged mitochondria from the cells. All of this is defined as cellular mitostasis, maintenance of which involves many cellular structures and, primarily, the cytoskeleton. This review summarizes the data on the role of one component of cytoskeleton, vimentin intermediate filaments, in these processes.
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