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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
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Exploring the association between pulse wave velocity and CKD progression: a longitudinal study in Mashhad, Iran
Susan Darroudi1, Naiemeh Varasteh1, Hayder Taha Yaseen2
1Vascular and Endovascular Surgery Research Center, Mashhad University of medical sciences, Mashhad, 99199-91766, Iran.
Scientific Reports
|December 26, 2025
Summary
Arterial stiffness, measured by pulse wave velocity (PWV), is a significant indicator of declining kidney function. Increased PWV correlates with reduced estimated glomerular filtration rate (eGFR), highlighting its role in chronic kidney disease progression.
Area of Science:
- Cardiovascular Medicine
- Nephrology
- Vascular Biology
Background:
- Arterial stiffness is an emerging vascular risk factor for renal failure.
- Non-invasive assessment of arterial stiffness offers a novel approach to understanding kidney disease.
- The relationship between arterial stiffness and chronic kidney disease (CKD) requires further investigation.
Purpose of the Study:
- To evaluate the correlation between non-invasive arterial stiffness measures and diminished glomerular filtration rate (GFR).
- To investigate the association between arterial stiffness markers and different stages of chronic kidney disease (CKD).
Main Methods:
- A cohort study of 787 participants (aged 35-65) from the MASHAD study in Iran.
- Assessment of arterial stiffness using pulse wave velocity (PWV), central augmentation index (CAI), and central aortic pressure (CAP).
- Participants were categorized into four groups based on estimated GFR (eGFR) levels.
Main Results:
- Pulse wave velocity (PWV) significantly increased as estimated GFR (eGFR) decreased, particularly in the lowest eGFR group (Group 4).
- A significant correlation was found between higher PWV and advanced CKD stages (Group 4).
- Each unit increase in PWV was associated with a 41.8% decline in eGFR after adjustment.
Conclusions:
- Arterial stiffness, specifically PWV, is a significant marker of deteriorating kidney function.
- PWV is independently associated with reduced eGFR, underscoring its role in CKD.
- Further research into the mechanisms linking arterial stiffness and impaired kidney function is recommended.
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