Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

3.7K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.7K
Epigenetic Regulation01:46

Epigenetic Regulation

33.4K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.4K
Phase II Reactions: Methylation Reactions01:17

Phase II Reactions: Methylation Reactions

655
Methylation is a phase II biotransformation process involving the attachment of a methyl group to a substrate. Enzymes known as methyltransferases orchestrate this reaction.
The mechanism of methylation unfolds in two stages. The first stage sees a methyltransferase enzyme facilitating the transfer of a methyl group from S-adenosylmethionine (SAM) to the substrate, forming S-adenosylhomocysteine (SAH). The second stage involves further metabolism of SAH into homocysteine, which can be recycled...
655
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

846
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
846
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

516
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
516
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

291
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
291

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Photobiomodulation-reprogrammed extracellular vesicles delivered <i>via</i> a biodegradable microneedle patch promote cardiac repair by enhancing glycolytic metabolism.

Acta pharmaceutica Sinica. B·2026
Same author

Bclaf1 drives heart failure by recruiting Srsf2 to enhance Hand2 pre-mRNA splicing and pathological hypertrophy.

Nature communications·2026
Same author

Three-dimensionally printed mesoporous bioactive glass for craniomaxillofacial bone regeneration: Material evolution, functional mechanisms, and clinical translation.

Cell transplantation·2026
Same author

Huatuo Zaizao Pills improve myocardial ischemia by inhibiting extracellular calcium influx.

Chinese journal of natural medicines·2026
Same author

In situ self-assembled stimulus-responsive and conductive hydrogel modulate myocardial infarction inflammatory homeostasis via PPARα/NFκB signaling and enhance the therapeutic efficacy of hiPSC-CMs.

Bioactive materials·2026
Same author

ALKBH3 suppresses ischemia/reperfusion-induced PANoptosis by regulating the ZBED6/STAT1/AIM2 axis through m<sup>1</sup>A demethylation.

Clinical and translational medicine·2026

Related Experiment Video

Updated: Jan 7, 2026

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images
09:42

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images

Published on: September 7, 2017

10.2K

Roles of different methylation modifications in cardiovascular disease.

Yuan Lin1,2,3,4, Jennifer Wang5, Xin Liu1,2,3

  • 1State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), College of Pharmacy, and Department of Cardiology, the Second Affiliated Hospital, Harbin Medical University, Harbin, 150081, China.

Frontiers of Medicine
|December 26, 2025
PubMed
Summary

Epigenetic methylation modifications, including DNA, protein, and RNA N6-methyladenosine (m6A) changes, are crucial in cardiovascular disease development. Understanding these epigenetic mechanisms offers new therapeutic targets for heart conditions.

Keywords:
DNA methylationcardiovascular diseasem6Aprotein methylation

More Related Videos

Exploring the Arginine Methylome by Nuclear Magnetic Resonance Spectroscopy
07:02

Exploring the Arginine Methylome by Nuclear Magnetic Resonance Spectroscopy

Published on: December 16, 2021

1.7K
Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
14:56

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Published on: May 6, 2022

5.0K

Related Experiment Videos

Last Updated: Jan 7, 2026

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images
09:42

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images

Published on: September 7, 2017

10.2K
Exploring the Arginine Methylome by Nuclear Magnetic Resonance Spectroscopy
07:02

Exploring the Arginine Methylome by Nuclear Magnetic Resonance Spectroscopy

Published on: December 16, 2021

1.7K
Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
14:56

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Published on: May 6, 2022

5.0K

Area of Science:

  • Molecular Biology
  • Cardiology
  • Epigenetics

Background:

  • Cardiovascular diseases (CVDs) are leading causes of global mortality and disability.
  • Effective prevention and therapy require deep understanding of molecular mechanisms.
  • Epigenetic modifications, particularly methylation, are increasingly recognized in CVD pathogenesis.

Purpose of the Study:

  • To review the biological processes of DNA, protein, and RNA N6-methyladenosine (m6A) methylation.
  • To summarize the roles of these methylation modifications in major cardiovascular diseases.
  • To highlight the potential of epigenetic mechanisms as therapeutic and diagnostic targets for CVDs.

Main Methods:

  • Literature review of recent advancements in epigenetic research.
  • Focus on methylation modifications: DNA methylation, protein methylation, and m6A RNA modification.
  • Synthesis of findings related to CVDs including cardiac hypertrophy, heart failure, ischemic heart disease, and atherosclerosis.

Main Results:

  • Methylation modifications significantly impact gene expression relevant to cardiovascular health.
  • Specific roles of DNA, protein, and m6A methylation are identified in cardiac hypertrophy, heart failure, ischemic heart disease, and atherosclerosis.
  • Epigenetic alterations are implicated in the progression and pathogenesis of various cardiovascular conditions.

Conclusions:

  • Epigenetic methylation modifications are integral to cardiovascular disease development and progression.
  • Targeting these methylation mechanisms presents promising avenues for novel diagnostic and therapeutic strategies in cardiology.
  • Further research into epigenetic modulation is critical for advancing cardiovascular medicine.