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Updated: Jan 7, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Published on: August 4, 2019

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The Multifaceted Role of p53 in Musculoskeletal Diseases: A Comprehensive Review

Marofe Hossain1,2,3, Sun Hao1,3, Ahamed Yeasin2

  • 1Northern Jiangsu People's Hospital, Yangzhou, China.

International Journal of Rheumatic Diseases
|December 27, 2025
PubMed
Abstract

Insights

The p53 gene plays a critical role in musculoskeletal diseases like osteoporosis and arthritis by influencing bone health and inflammation. Targeting p53 offers potential therapeutic strategies for these conditions.

Area of Science:

  • Molecular Biology
  • Genetics
  • Rheumatology

Background:

  • The p53 gene, traditionally known for tumor suppression, is increasingly recognized for its role in musculoskeletal disorders.
  • Aberrant p53 expression contributes to the pathogenesis and progression of various bone and joint diseases.

Purpose of the Study:

  • To systematically review the roles of p53 in major musculoskeletal diseases.
  • To analyze the molecular mechanisms underlying p53's involvement.
  • To evaluate p53 as a potential therapeutic target.

Main Methods:

  • Comprehensive literature search of PubMed (Jan 2008-Mar 2025).
  • Keywords: P53, osteoporosis, osteoarthritis, rheumatoid arthritis, gout, low back pain, scoliosis.
  • Analysis of 90 relevant original research articles, reviews, and clinical trials.

Main Results:

  • p53 influences osteoporosis by disrupting bone formation/resorption (p53-Nedd4-Runx2 axis).
  • p53 promotes chondrocyte apoptosis in osteoarthritis (miR-34a-SIRT1-p53 pathway).
  • p53 modulates inflammatory mediators (TNF-α, IL-6) in rheumatoid arthritis and oxidative stress in gout (p53-SLC2A9 axis).

Conclusions:

  • p53 critically impacts musculoskeletal disease development and progression through diverse mechanisms.
  • p53 has dual roles, requiring precise therapeutic targeting strategies.
  • Interventions like gene editing, small-molecule inhibitors, and natural products show promise but need clinical validation.
Keywords:
goutlower back painmusculoskeletal diseasesosteoarthritisosteoporosisp53rheumatoid arthritisscoliosis

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