High-Entropy Alloy-Based Artificial Enzymes With Modulated D-Band Center and pH-Controllable ROS Biocatalysis for...

Area of Science:

• Biomaterials Science
• Nanotechnology
• Materials Chemistry

Background:

• Periodontitis involves complex biofilms and oxidative stress, challenging current treatments.
• Existing therapies struggle with simultaneous biofilm removal and inflammation control.

Purpose of the Study:

• To design novel high-entropy alloy (HEA, PtPdRuRhIr)-based artificial enzymes.
• To achieve pH-controllable reactive oxygen species (ROS) biocatalysis for stage-specific periodontitis treatment.

Main Methods:

• De novo design of PtPdRuRhIr HEA with modulated d-band center.
• Evaluation of ROS biocatalysis and pH-dependent switching (antioxidase/peroxidase activity).
• In vitro and in vivo assessments of anti-inflammatory, regenerative, and antibacterial effects.

Main Results:

• The HEA structure optimizes ROS biocatalysis and exhibits pH-controllable activity.
• The HEA demonstrated regenerative functions by reducing oxidative damage.
• In vivo studies showed suppressed inflammation, alveolar bone regeneration, and biofilm disruption.

Conclusions:

• PtPdRuRhIr HEA acts as a smart biocatalyst with dual anti-inflammatory and antimicrobial properties.
• This nanoplatform integrates immunomodulatory capacity for periodontitis treatment.
• The HEA offers a promising strategy for biofilm-associated inflammatory disorders, bridging microbial clearance and tissue restoration.