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Triglyceride-glucose index as a novel predictor of major adverse cardiovascular events in patients with coronary

Chunyu Zhang1, Minghao Li1, Lin Liu1

  • 1Department of Cardiology, The Affiliated Hospital of Southwest Medical University, Stem Cell Immunity and Regeneration Key Laboratory of Luzhou, Luzhou, China.

Annals of Medicine
|December 27, 2025
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The triglyceride-glucose (TyG) index is linked to increased cardiovascular events after coronary revascularization. A higher TyG index indicates a greater risk of major adverse cardiovascular events (MACEs) in these patients.

Keywords:
Triglyceride-glucose indexcardiovascular disease riskcoronary revascularizationmeta-analysis

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Area of Science:

  • Cardiology
  • Metabolic Syndrome
  • Biomarkers

Background:

  • The triglyceride-glucose (TyG) index is emerging as a valuable indicator for assessing insulin resistance (IR).
  • Coronary revascularization procedures aim to improve outcomes for patients with coronary artery disease.
  • Understanding predictors of cardiovascular events post-revascularization is crucial for patient management.

Purpose of the Study:

  • To systematically evaluate the association between the TyG index and the occurrence of major adverse cardiovascular events (MACEs) in patients who have undergone coronary revascularization.
  • To summarize the prognostic significance of the TyG index in this patient population.

Main Methods:

  • A comprehensive literature search was conducted across PubMed, Web of Science, Embase, and The Cochrane Library.
  • Meta-analysis was performed using risk ratios (RR) and 95% confidence intervals (CI) to assess the correlation between TyG index and MACEs.
  • Sensitivity and subgroup analyses were employed to investigate heterogeneity and confirm result stability.

Main Results:

  • Twelve studies comprising 9,973 participants were included in the analysis.
  • A high TyG index was significantly associated with an increased risk of MACEs in patients undergoing coronary revascularization (RR: 2.0, 95% CI: 1.71-2.35).
  • Subgroup analyses confirmed this association for both CABG (RR: 2.10) and PCI (RR: 1.94) procedures, and the TyG index also predicted all-cause mortality, myocardial infarction, stroke, and repeat revascularization.

Conclusions:

  • Elevated TyG index is independently associated with a higher incidence of MACEs in patients following coronary revascularization.
  • The TyG index serves as a significant prognostic biomarker for adverse cardiovascular outcomes in this cohort.
  • These findings underscore the importance of monitoring the TyG index in patients undergoing coronary revascularization.