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Interval appendicitis.

Badr AbdullGaffar1, Fatma B Zarooni2, Mohamed Alaqqad3

  • 1Pathology Section, Dubai Hospital, Dubai, United Arab Emirates.

Annals of Diagnostic Pathology
|December 27, 2025
PubMed
Summary
This summary is machine-generated.

Histopathologic findings in interval appendectomies and stump appendectomies reveal distinct postinflammatory changes. While both show acute inflammation, interval appendectomies present more granulomatous inflammation and diverticulosis.

Keywords:
AppendixChronic inflammationDelayed appendectomyGranulomasIntervalOrganizingStumpXanthogranulomatous

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Area of Science:

  • Gastroenterology
  • Pathology

Background:

  • Histopathologic findings in interval appendectomies are less studied compared to acute appendicitis.
  • Understanding these findings is crucial for differentiating postinflammatory changes from neoplastic conditions.

Purpose of the Study:

  • To compare the histopathologic features of interval appendectomies with a control group of stump appendectomies.
  • To identify distinct patterns and differences in chronic inflammatory changes between the two groups.

Main Methods:

  • Retrospective review of 10-year data for interval appendectomies and stump appendectomies.
  • Analysis of histopathologic patterns including inflammatory infiltrates, structural changes, and other findings.
  • Statistical comparison of features between the interval and stump appendectomy groups.

Main Results:

  • Interval appendectomies (n=21) showed xanthogranulomatous (48%), Crohn-like (33%), and granulomatous inflammation (33%).
  • Stump appendectomies (n=11) showed xanthogranulomatous and Crohn-like changes (45%), but no epithelioid granulomas.
  • Significant differences were observed in granulomatous inflammation, diverticulosis, mucosal hyperplasia, mucin pools, fibrous obliteration, appendicolith, and Actinomyces between the groups.

Conclusions:

  • Interval and stump appendectomies exhibit varied subacute to chronic postinflammatory organizing reparative processes.
  • Distinct histopathologic differences exist, particularly in granulomatous inflammation and diverticulosis, between interval and stump appendectomies.
  • No appendiceal neoplasms were detected in interval appendectomies, though some cases mimicked mucinous neoplasms.