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Published on: February 28, 2021
Cannabis use in chronic pancreatitis: A narrative review
Darius J Javidi1, Timothy B Gardner1
1Center for Digestive Heath, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.
Abstract:
Chronic pain is a debilitating complication of chronic pancreatitis for which treatment options are limited. The goal of this narrative review was to summarize the existing evidence surrounding use of cannabis and its derivatives in chronic pancreatitis patients. Cannabis use in chronic pancreatitis is increasing and more prevalent in patients who are younger, male, take opioids chronically, and have chronic abdominal pain. In one retrospective study medical cannabis was associated with decreased mean daily opioid use while in a randomized control trial THC did not significantly decrease abdominal pain. Several very low-quality studies showed improved outcomes in hospitalized chronic pancreatitis patients who used cannabis. The existing evidence surrounding cannabis use in chronic pancreatitis is limited and mostly low-quality. Further investigation is warranted to explore whether medical cannabis could represent an effective therapy for patients with chronic pancreatitis.
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