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Organelles and cancer cell pyroptosis: overview and perspectives

AnPeng Qiu1, JunDa Lin1, HaoRan Hu1

  • 1Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, Guangdong, 510280, China.

Cell Death & Disease
|December 27, 2025
PubMed

Insights

Pyroptosis, a programmed cell death, offers cancer immunotherapy benefits by altering tumors and boosting immunity. This review explores organelle roles in pyroptosis signaling and targeted therapies for improved cancer treatment.

Area of Science:

  • Immunology
  • Cell Biology
  • Oncology

Background:

  • Pyroptosis is a gasdermin (GSDM)-mediated programmed cell death.
  • It involves membrane permeabilization and pro-inflammatory cytokine release.
  • Pyroptosis has therapeutic potential in cancer immunotherapy by remodeling the tumor microenvironment and enhancing anti-tumor immunity.

Purpose of the Study:

  • To systematically explore organelle-specific ultrastructural alterations during pyroptosis.
  • To investigate the molecular machinery regulating organelle-mediated pyroptotic pathways.
  • To synthesize recent advances in organelle-targeted pyroptosis induction strategies and inter-organelle crosstalk.

Main Methods:

  • Systematic literature review of organelle-specific changes in pyroptosis.
  • Analysis of molecular mechanisms governing organelle-mediated pyroptosis.
  • Synthesis of current research on organelle-targeted pyroptosis induction strategies.

Main Results:

  • Pyroptosis involves significant ultrastructural changes in various organelles.
  • Inter-organelle communication plays a crucial role in pyroptotic signaling.
  • Organelle-targeted strategies show promise for enhancing pyroptosis induction.

Conclusions:

  • Understanding organelle dynamics in pyroptosis is key to optimizing cancer therapy.
  • Targeting inter-organelle crosstalk can enhance pyroptosis-based cancer treatments.
  • This review provides a framework for developing novel translational approaches in cancer immunotherapy.

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