Related Experiment Video

Updated: Jul 10, 2026

Isolation of Region-specific Microglia from One Adult Mouse Brain Hemisphere for Deep Single-cell RNA Sequencing
09:49

Isolation of Region-specific Microglia from One Adult Mouse Brain Hemisphere for Deep Single-cell RNA Sequencing

Published on: December 3, 2019

11.5K

Exploring cellular heterogeneity: single-cell and spatial transcriptomics of Alzheimer's disease brains and

Anjali Garg1,2, Sheeny Vo3, Iara D De Souza4

  • 1Department of Psychiatry, Washington University, Saint Louis, St. Louis, MO, USA.

Alzheimer'S Research & Therapy
|December 28, 2025
PubMed
Abstract

No abstract available in PubMed .

Keywords:
Alzheimer’s diseaseAmyloid betaImmunofluorescence stainingIntegrationMicrogliaSingle-nucleus RNA-seqSpatially resolved transcriptomicsTau

More Related Videos

Isolation of Mouse Primary Microglia by Magnetic-Activated Cell Sorting in Animal Models of Demyelination
04:53

Isolation of Mouse Primary Microglia by Magnetic-Activated Cell Sorting in Animal Models of Demyelination

Published on: April 5, 2022

4.1K
Author Spotlight: Exploring Sex-Specific Glial Signatures and Therapeutic Leads for Alzheimer's Disease
04:22

Author Spotlight: Exploring Sex-Specific Glial Signatures and Therapeutic Leads for Alzheimer's Disease

Published on: May 20, 2024

1.3K

Related Experiment Videos

Last Updated: Jul 10, 2026

Isolation of Region-specific Microglia from One Adult Mouse Brain Hemisphere for Deep Single-cell RNA Sequencing
09:49

Isolation of Region-specific Microglia from One Adult Mouse Brain Hemisphere for Deep Single-cell RNA Sequencing

Published on: December 3, 2019

11.5K
Isolation of Mouse Primary Microglia by Magnetic-Activated Cell Sorting in Animal Models of Demyelination
04:53

Isolation of Mouse Primary Microglia by Magnetic-Activated Cell Sorting in Animal Models of Demyelination

Published on: April 5, 2022

4.1K
Author Spotlight: Exploring Sex-Specific Glial Signatures and Therapeutic Leads for Alzheimer's Disease
04:22

Author Spotlight: Exploring Sex-Specific Glial Signatures and Therapeutic Leads for Alzheimer's Disease

Published on: May 20, 2024

1.3K

Related Concept Videos

iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...

Articles linked to this work by shared authors, journal, and citation graph.

Personalized Neoantigen Vaccines Synergize with Immune Checkpoint Therapy and CD8-Targeted Cytokines to Control B-Cell Lymphoma.

bioRxiv : the preprint server for biology·2026

An end-to-end framework for single-cell-resolution, whole-transcriptomic spatial profiling in post-mortem human brain.

bioRxiv : the preprint server for biology·2026

Repurposing drugs for treating dengue haemorrhagic fever and associated autoimmune diseases.

In silico pharmacology·2026

Decarboxylative alkylation of unactivated olefins via photoinduced Fe-LMCT: access to alkylated dihydropyrazoles/tetrahydropyridazines.

Chemical communications (Cambridge, England)·2026

Alternating copolymerization of l-lactide and ε-caprolactone via enantiomorphic site and chain-end synergistic control.

Chemical science·2026

Maternal-fetal type I interferon signaling drives TREM2 dysregulation and synaptic dysfunction in neurodevelopmental disorders.

Neuron·2026

Association of self-reported hearing loss and tinnitus with brain structure and cognitive function: a population-based cross-sectional analysis from the Study of Health in Pomerania (SHIP).

Alzheimer's research & therapy·2026

The UNC13A cryptic exon associates with cognitive impairment in Alzheimer's disease.

Alzheimer's research & therapy·2026

Semantic fluency predicts survival of memory clinic patients.

Alzheimer's research & therapy·2026

SuperAging is not the inverse of common-variant Alzheimer's risk: evidence across genetic ancestries.

Alzheimer's research & therapy·2026

Personalized non-invasive combined magnetic and electrical stimulation of the default mode network in mild AD patients (CMES-AD): a multicentric randomized sham-controlled trial protocol.

Alzheimer's research & therapy·2026

Blood-based immunophenotyping of T cell profiles in patients with neurodegenerative disorders.

Alzheimer's research & therapy·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
Jove
Visualize
Contact Us