Network toxicology analysis of hair dye components and their association with breast and bladder cancers

Area of Science:

• Toxicology
• Molecular Biology
• Cancer Research

Background:

• Hair dye use is widespread, raising concerns about potential health risks.
• Understanding the molecular mechanisms of hair dye-induced carcinogenesis is crucial for public health.

Purpose of the Study:

• To investigate the toxic effects and molecular mechanisms of hair dye components.
• To explore the relationship between hair dye exposure and breast and bladder cancer risk.

Main Methods:

• Employed a network toxicology approach.
• Integrated data from multiple databases.
• Performed Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses.
• Conducted network and molecular docking analyses.

Main Results:

• Identified key molecular targets and pathways involved in hair dye toxicity.
• Revealed that major hair dye chemicals may induce carcinogenesis via xenobiotic metabolism.
• Demonstrated interactions between hair dye chemicals and critical cancer-related proteins.

Conclusions:

• Findings provide theoretical support for health risks associated with hair dye exposure.
• Offers insights into potential preventive strategies against hair dye-induced cancers.
• Highlights the role of network toxicology in understanding chemical carcinogenesis.