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Adiponectin 1 receptor is increased but not adiponectin levels in the tumour microenvironment of postmenopausal women

Diego García-Mata1,2, Alberto Tenorio-Torres3,4, Ramón Mauricio Coral-Vázquez5,6

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Adiponectin receptor 1 (ADIPOR1) was higher in breast tumors than surrounding fat tissue in postmenopausal women. Obesity was linked to higher ADIPOR1 in adjacent fat tissue, especially in more aggressive breast cancers.

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Area of Science:

  • Endocrinology
  • Oncology
  • Metabolic Syndrome

Background:

  • Investigating adiponectin (ADIPOQ) and its receptor (ADIPOR1) in breast cancer.
  • Hypothesizing lower ADIPOQ and ADIPOR1 in obese postmenopausal women's tumor microenvironment.

Purpose of the Study:

  • Analyze ADIPOQ and ADIPOR1 levels in breast tumor and adjacent adipose tissue.
  • Compare levels between obese and normal BMI postmenopausal women with breast cancer.

Main Methods:

  • Western blot analysis of ADIPOQ and ADIPOR1 in tumor and adipose tissue.
  • Included 20 normal BMI and 20 obese postmenopausal women with breast cancer.

Main Results:

  • ADIPOR1 was significantly higher in tumor tissue than adjacent adipose tissue in both BMI groups.
  • Obese women with larger tumors (>2.0 cm) or advanced stage (II/III) showed higher ADIPOR1 in adjacent adipose tissue.
  • No significant differences in ADIPOQ levels were observed between groups.

Conclusions:

  • ADIPOR1 is upregulated in breast tumor tissue compared to adjacent adipose tissue.
  • Elevated ADIPOR1 in adipose tissue is associated with obesity and more aggressive breast tumors in postmenopausal women.