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Related Concept Videos

Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...

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A randomized Phase II trial of High Dose-Rate (HDR) and Low Dose-Rate (LDR) brachytherapy as monotherapy in localized prostate cancer: analysis of initial arms of Canadian cancer trials group PR19 (NCT02960087).

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2025
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Uncovering the armpit of SBRT: An institutional experience with stereotactic radiation of axillary metastases.

Clinical and translational radiation oncology·2024
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Brachytherapy for high grade prostate cancer induces distinct changes in circulating CD4 and CD8 T cells - Implications for systemic control.

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Severe kyphosis and stereotactic lung radiation therapy set-up: A case report and lessons learned.

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Updated: Jul 18, 2026

Stereotactic Radiosurgery for Gynecologic Cancer
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Stereotactic Body Radiotherapy for Extracranial Oligometastatic Pancreatobiliary Cancer.

A N Mian1, S Myrehaug1, S Ng1

  • 1Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada.

Clinical Oncology (Royal College of Radiologists (Great Britain))
|December 28, 2025
PubMed
Summary

Stereotactic body radiotherapy (SBRT) shows promise for treating oligometastatic pancreatobiliary cancers, delaying progression with manageable toxicity. Further research is needed to optimize its integration into multidisciplinary care for this aggressive disease.

Keywords:
Oligometastasispancreatobiliary malignancystereotactic body radiotherapy

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Area of Science:

  • Oncology
  • Radiation Oncology
  • Gastroenterology

Background:

  • Stereotactic body radiotherapy (SBRT) is increasingly used for oligometastatic disease across various cancer types to delay progression.
  • Data on SBRT efficacy in pancreatobiliary cancers is limited due to their rarity and aggressive nature.

Purpose of the Study:

  • To evaluate the outcomes of extracranial SBRT in patients with oligometastatic pancreatobiliary cancers.
  • To assess local failure, progression-free survival, systemic therapy changes, and overall survival after SBRT.

Main Methods:

  • Retrospective review of 62 patients with oligometastatic pancreatobiliary cancer treated with extracranial SBRT (2014-2023).
  • Analysis included cumulative incidence of local failure (LF), progression-free survival (PFS), systemic therapy changes (SCST), overall survival (OS), and toxicities.
  • Kaplan-Meier and Cox proportional hazard models were used for survival analysis.

Main Results:

  • The study included 115 lesions in 62 patients (71% pancreatic, 15% cholangiocarcinoma, 15% ampullary).
  • At 12 months, LF was 21.5%, PFS was 28.0%, SCST was 33.6%, and OS was 61.7%.
  • Higher planning target volume (PTV) was the only predictor of worse PFS; no grade 3-5 toxicities were reported.

Conclusions:

  • Extracranial SBRT is a promising treatment option for oligometastatic pancreatobiliary cancers, similar to other histologies.
  • Further research is warranted to optimize SBRT integration within a multidisciplinary approach for managing this challenging disease.