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Simulating Endoscopic Transsphenoidal Surgery in a 3D Model and the Cadaver: A Preliminary Comparative Study
Cesare Zoia1, Pier Paolo Mattogno2, Luca Perna3
1Neurosurgery Unit, Ospedale Moriggia Pelascini, Gravedona e Uniti, Italy.
World Neurosurgery
|December 28, 2025
Summary
This study shows that initial training with the UpSurgeOn TNSBox (transnasal transsphenoidal surgical simulator) significantly improves endoscopic surgical skills for both residents and specialists.
Area of Science:
- Neurosurgery
- Surgical Education
- Medical Simulation
Background:
- Endoscopic endonasal and transnasal procedures present significant surgical training challenges.
- Three-dimensional (3D) simulators offer a potential solution for cost-effective skill acquisition.
- Limited validation studies exist for current 3D surgical simulators.
Purpose of the Study:
- To evaluate the effectiveness of the UpSurgeOn TNSBox (transnasal transsphenoidal surgical simulator) in surgical skill enhancement.
- To compare the simulator's role in surgical training against traditional cadaveric dissection.
Main Methods:
- 34 neurosurgeons and head and neck surgeons (residents and junior consultants) participated.
- Group 1: 3D simulator training followed by cadaveric dissection. Group 2: Cadaveric dissection only.
- Performance was assessed by blinded experts using the Endoscopic Surgery Rating Scale (G.R.S.) and analyzed via Student's t-tests.
Main Results:
- Simulation-based initial training significantly improved surgical skills for both residents and specialists.
- Participants undergoing simulation-based training showed enhanced proficiency in endoscopic transsphenoidal surgery.
Conclusions:
- The UpSurgeOn TNSBox is a valuable tool for surgical training.
- It can be integrated into a hybrid training model combining simulation and cadaveric dissection.
- This approach enhances the acquisition of fundamental endoscopic surgical skills.

