Related Experiment Video
Updated: May 10, 2026
Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System
Published on: December 7, 2012
Unusual Icteric Discoloration of Single Donor Platelets in Platelet Additive Solution With Container Staining: A Rare
Suvetha Rajendran1, Harsha Unni1, Mohandoss Murugesan1
1Transfusion Medicine, Malabar Cancer Centre, Postgraduate Institute of Oncology Sciences and Research, Thalassery, India.
Abstract:
This report describes an unusual case of an apheresis platelet (AP) unit in platelet additive solution (PAS) exhibiting marked icteric discoloration and bag staining, despite sterile cultures and initially preserved platelet morphology. Donor evaluation revealed mild unconjugated hyperbilirubinemia, implicating donor-derived pigments as the source of discoloration. By Day 5, reduced platelet function was observed. This case underscores that icteric appearance in PAS-suspended platelets, though rare, may signal donor-related pigment transfer and warrants reevaluation of current visual inspection and acceptance for blood components.
Related Concept Videos
02:45Blood Transfusion and Agglutination
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
01:15Blood Transfusion
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...