Related Experiment Video
Updated: Jan 7, 2026
08:57
En Face Endocardial Cushion Preparation for Planar Morphogenesis Analysis in Mouse Embryos
Published on: July 27, 2022
2.0K
Linking Planar Cell Polarity to Mechanotransduction During Morphogenesis
Ksenia S Egorova1, Sergei Y Sokol1
1Department of Stem Cell Biology and Regenerative Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Summary
Planar cell polarity (PCP) establishment is linked to mechanical forces during embryonic development. This review explores how mechanical stresses influence PCP and how PCP signaling regulates tissue forces for proper morphogenesis.
Area of Science:
- Developmental Biology
- Cell Biology
- Biophysics
Background:
- Mechanical forces are crucial cues in embryonic development.
- Planar cell polarity (PCP) is essential for epithelial morphogenesis.
- The interplay between PCP and mechanical signaling is not fully understood.
Purpose of the Study:
- To review evidence linking PCP and mechanotransduction.
- To explore how mechanical stresses establish PCP.
- To investigate the role of PCP signaling in tissue mechanics.
Main Methods:
- Literature review of existing research.
- Analysis of data on PCP establishment and mechanotransduction.
- Hypothesizing a regulatory loop between PCP and mechanical forces.
Main Results:
- PCP can be established in response to mechanical stresses.
- PCP signaling influences physical force generation in tissues.
- A positive feedback loop connects PCP and mechanotransduction.
Conclusions:
- Mechanochemical feedback involving PCP is vital for morphogenesis.
- PCP acts as a sensor and regulator of mechanical forces.
- This mechanism ensures correct tissue shape and positioning during development.
Keywords:
Xenopusactomyosinapical junctionscytoskeletonembryonic epitheliamechanical forcemechanochemical loopmorphogenesisneural tube closureplanar cell polaritytensionMore Related Videos
Related Concept Videos
01:31Mechanism of Lamellipodia Formation
3.5K
Cells migrating in response to external stimuli form lamellipodia, which are thin membrane protrusions supported by a mesh of linked, branched, or unbranched actin filaments. These actin filaments interact with myosin motor proteins, creating the dynamic actomyosin complex within the cytoskeleton. Contractility, or the ability to generate contractile stress, is inherent to the actomyosin complex. It helps cells detect the stiffness of the surrounding ECM and exert contractile force for...
3.5K
01:32Cytoskeletal Coordination in Cell Migration
5.4K
A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
5.4K
01:21Cell Polarization by Rho Proteins
3.5K
Cell polarity is the asymmetric distribution of cellular and membrane components, making one side of the cell different from the other. This polarity is essential to many processes such as embryogenesis, axon migration, glucose transport across epithelial cells, and directional cell migration. A migrating cell responds to intracellular or extracellular signals via molecular cascades that reorganize the actin cytoskeleton to establish this polarity. In these cells, the Rho family proteins Cdc42,...
3.5K
01:39Mechanism of Filopodia Formation
3.0K
Filopodia are thin, actin-rich cellular protrusions that play an important role in many fundamental cellular functions. They vary in their occurrence, length, and positioning in different cell types, suggesting their diverse roles.
Their main function is to guide migrating cells during normal tissue morphogenesis or cancer metastasis by recognizing and making initial contacts with the extracellular matrix. However, they can also act as stationary cell anchors or help to establish communication...
Their main function is to guide migrating cells during normal tissue morphogenesis or cancer metastasis by recognizing and making initial contacts with the extracellular matrix. However, they can also act as stationary cell anchors or help to establish communication...
3.0K
01:09Cell Migration
18.5K
Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
18.5K
01:19Cell Migration
6.3K
Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
6.3K