Depression: epigenetics and epitranscriptomic modifications

This study aims to explore the potential interconnection among epigenetic alteration, epitranscriptomic modifications, and Major Depressive Disorder (MDD). Additionally, it tries to identify potential therapeutic interventions in depression by understanding the molecular mechanisms in DNA and RNA-based regulation.

To achieve these goals, we reviewed the recent and updated existing literature, critical reviews and encompassing studies that fall under the domain of MDD, epigenetic and epitranscriptomic alteration.

These findings highlight a notable association between chromatin-level modifications and RNA-level regulatory changes in the context of MDD. MDD is largely the result of genetic vulnerability conferred by the combined actions of many genes. Additionally, environmental factors, including early-life stress, contribute substantially to the development of MDD. Our review draws attention to the expanding focus in depression research, which includes posttranscriptional RNA modifications alongside DNA epigenetic changes.

MDD is a psychiatric disorder characterised by persistent sadness, diminished energy, and sleep disturbances, that affects millions of individuals worldwide. Besides providing a better and more detailed understanding of the molecular mechanisms underlying MDD, information from this review could aid in the identification of chromatin-RNA regulators and pathways as potential targets in developing effective therapeutics for MDD.