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Related Concept Videos

Bioplastics01:27

Bioplastics

Bioplastics derived from microbial processes present a sustainable alternative to conventional petroleum-based plastics. Among these, polyhydroxyalkanoates (PHAs), particularly polyhydroxybutyrates (PHBs), have emerged as prominent candidates due to their biodegradability and biocompatibility. These polymers are synthesized by a variety of bacteria, such as Cupriavidus necator and Pseudomonas putida, which naturally accumulate PHAs as intracellular carbon and energy reserves, especially under...

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Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications
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Degradable Polyurethane with a Zwitterionic Precursor for Healthy Healing.

Haoyu Xiong1, Jun Ma1, Shengfu Chen1

  • 1Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China.

ACS Applied Bio Materials
|December 29, 2025
PubMed
Summary
This summary is machine-generated.

This study developed a new degradable synthetic elastomer using carboxybetaine ester (CBE) and polylactide (PLA) that promotes healthy tissue healing by resisting protein adsorption and maintaining pH. Optimized PLA/CBE implants showed accelerated fur regrowth and no fibrous encapsulation, unlike PLA controls.

Keywords:
healthy healinghydrolysisnonfoulingpolylactidepolyurethanezwitterionic material

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Regenerative Medicine

Background:

  • Synthetic elastomers often trigger adverse foreign body reactions and inflammation due to degradation byproducts.
  • Polylactide (PLA) degradation leads to tissue acidification, exacerbating inflammation and hindering healthy healing.
  • Existing degradable elastomers lack sufficient biocompatibility for optimal tissue regeneration.

Purpose of the Study:

  • To synthesize and evaluate a novel degradable polyurethane elastomer incorporating carboxybetaine ester (CBE) analogues and polylactide (PLA).
  • To assess the elastomer's ability to resist nonspecific protein adsorption and maintain physiological pH.
  • To investigate the in vivo healing response to the optimized elastomer formulation after subcutaneous implantation.

Main Methods:

  • Synthesis of a degradable polyurethane incorporating CBE analogues and PLA.
  • Evaluation of protein adsorption resistance and pH stability after hydrolysis.
  • Subcutaneous implantation of optimized PLA/CBE (1:1) formulation and PLA controls in vivo.
  • Histological analysis and assessment of fur regrowth at 6 weeks post-implantation.

Main Results:

  • The optimized PLA/CBE (1:1) formulation demonstrated excellent resistance to nonspecific protein adsorption.
  • Implantation of the optimized formulation resulted in no collagen deposition and accelerated fur regrowth.
  • PLA controls exhibited significant fibrous encapsulation, indicating a foreign body response.
  • The CBE analogues helped maintain a balanced physiological pH, reducing implant-induced acidification.

Conclusions:

  • The developed PLA/CBE elastomer promotes healthy healing by mitigating foreign body reactions and inflammation.
  • Surface zwitterion regeneration and pH buffering by CBE analogues are key to the improved biocompatibility.
  • This research presents a promising strategy for designing degradable synthetic elastomers for enhanced tissue regeneration.