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Updated: Jan 7, 2026

Genetic Engineering of an Unconventional Yeast for Renewable Biofuel and Biochemical Production
Published on: September 20, 2016
[Advances in metabolic engineering of common yeast species]
Shichang Liu1,2, Jiaoqi Gao1,2, Yongjin Zhou1,2
1Division of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, Liaoning, China.
Abstract:
Yeast cells are the preferred microbial chassis for metabolic engineering and have been engineered into microbial cell factories for producing biofuels, materials, and chemicals. The development of gene editing technologies and synthetic biology tools has significantly accelerated the metabolic engineering in yeast, enabling the design of complex metabolic pathways and comprehensive metabolic rewiring. This review introduces the physiological characteristics of several common yeast species, compares their advantages and disadvantages as chassis cells for biosynthesis, and shows their current applications. We then summarize the latest research progress in metabolic engineering strategies. Finally, the future research directions of yeast metabolic engineering are prospected in light of the latest technological advances. This review will guide the development and engineering applications of next generation yeast chassis cells.
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