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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
[Role of sterol-C4-methyl oxidase-like in sterol synthesis]
Ruixue Zhnag1,2, Mingqi Zang1,2, Jiaojiao Lu1,2
1College of Life Sciences, Northeast Forestry University, Harbin 150040, Heilongjiang, China.
Abstract:
Sterols play a crucial role in the growth and development of organisms, as well as in the construction of cell membranes. The biosynthesis of sterols is a complex metabolic process involving multiple enzymatic reactions. The removal of two methyl groups at the C-4 position by the sterol-C4-methyloxidase-like (SC4MOL) is an important step in sterol functionalization. This paper provides a systematic review of the critical role of SC4MOL in sterol biosynthesis. It specifically elaborates on SC4MOL in terms of the composition, catalytic mechanism, and functional diversity across different organisms in processes such as growth, development, and resistance to diseases and stress. The review lays a foundation for further research into the regulation of sterol metabolism.
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