[Multi-technology integration and feedstock innovation drive biomanufacturing development]

As the driving force of the bioeconomy, biomanufacturing is facilitating the transition of current production feedstocks and methods toward green and sustainable alternatives. Bioproducts are expected to span multiple sectors including energy, chemicals, materials, food, pharmaceuticals, and agriculture, exemplified by biofuels such as lignocellulosic ethanol and sustainable aviation fuel (SAF), biodegradable materials such as polylactic acid (PLA) and polyhydroxyalkanoates (PHA), as well as other high-value bioproducts such as microbial proteins, functional sugars, collagens, and bio-based dyes. This review explores the future directions of biomanufacturing in three aspects: sustainable feedstocks, robust microbial strains, and automatic production processes. Specifically, it includes the shift of feedstocks from grain crops towards low-carbon resources such as non-grain biomass and CO₂, the rational design and efficient construction of industrial strains through advanced genome editing, automated platforms, and artificial intelligence (AI) technologies, and the precise regulation and optimization of production processes combining Raman spectroscopy, automated equipment, and intelligent control. By enhancing multi-technology integration, improving the industrial chain, and deepening international cooperation, the challenges faced by current biomanufacturing in technology innovation, feedstock supply, and policy systems can be overcome. This will enable biomanufacturing to capture a significant share of the global manufacturing industry and become a pivotal force in leading the high-quality development of the bioeconomy. This review aims to draw attentions to biomanufacturing technology and deepen our understanding of the bioeconomy for promoting biomanufacturing industry in China.