Pediatric Giant Cell Fibroblastoma: A Review of Treatment and Outcomes

Giant cell fibroblastoma (GCF) is a rare predominantly pediatric tumor with frequent local recurrence that has clinical and histological similarities with DFSP. We conducted a literature review of published pediatric GCF cases to review demographics, management and outcomes. We identified 104 pediatric GCF cases from 52 articles, of which 81 were treated with excision of unspecified margins (EUM), 17 with wide local excision (WLE), two with Mohs micrographic surgery (MMS), and one with chemotherapy. Local recurrence was noted in 38/104 (36.5%); given the high recurrence rates of GCF following excision, and the advantages of MMS in treating DFSP, MMS is an important consideration for GCF when logistically possible.