Efficacy of a Novel Daily-Use Hydrocolloid Pad on Wound Healing: Findings of a 16-Day, Single-Center, Randomized,...

To evaluate wound healing with a novel bandage with hydrocolloid pad designed for daily use/replacement in a new model of laser-induced burns/wounds.

In this randomized, controlled, single-center, 16-day study, healthy adults aged 25-55 years of age with Fitzpatrick skin type I-III and who met all eligibility criteria (N = 34) had four laser-induced wounds generated on each arm and were randomized as follows: (1) uncovered wound (control); (2) standard of care bandage (SoC); (3) petrolatum-based antibiotic ointment + SoC (petrolatum + SoC); (4) bandage with hydrocolloid pad.

composite healing score (sum of scores for general wound appearance, smoothness, and epithelial confluence, minus scores for erythema, edema, and crusting/scabbing) on Days 1-7.

Mean composite healing score was significantly better with the hydrocolloid pad (Days 1-7) and petrolatum + SoC (Days 2-7) than SoC, and with either treatment than untreated controls (Days 1-7), and significantly better with the hydrocolloid pad than petrolatum + SoC (Days 1 to 2 and 7). The hydrocolloid pad and petrolatum + SoC both significantly reduced crusting/scabbing while improving epithelial confluence, smoothness, and general wound appearance, compared with untreated controls and SoC.

A laser-induced burn model producing consistent wounds was used to evaluate healing with a novel bandage with hydrocolloid pad versus other typical treatments.

Wound healing with the novel bandage with hydrocolloid pad used daily was superior to SoC (Days 1-7), untreated wound (Days 1-7), and petrolatum + SoC (Days 1 to 2 and 7). [Figure: see text].