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Updated: Jan 7, 2026

Quantitative Polymerase Chain Reaction-based Analyses of Murine Intestinal Microbiota After Oral Antibiotic Treatment
Published on: November 17, 2018
Duration of antibiotic therapy: with or without biomarkers?
Gonçalo Sequeira Guerreiro1, João Fustiga1, Pedro Póvoa1,2,3,4
1Department of Critical Care Medicine, Hospital de São Francisco Xavier, Unidade Local de Saúde de Lisboa Ocidental, Lisbon, Portugal.
Abstract:
Antimicrobial resistance has emerged as a critical global health challenge. Significant variability in antibiotic prescribing practices underscores the urgent need for high-quality evidence to inform optimal antibiotic prescribing policies. The ideal duration of antimicrobial therapy remains uncertain, and a one-size-fits-all approach is far from ideal. In this review, we examine bacterial growth kinetics and antibiotic pharmacodynamics and explore various strategies for determining the duration of antibiotic therapy: fixed duration, biomarker-guided, clinical course-based, and the more recent double-trigger approach.
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