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Conversion Surgery after Complete Response to Immune Checkpoint Inhibitor-Based Sequential Chemotherapy for Initially

Takahiro Tomino1, Keishi Sugimachi1, Tadatoshi Kakimoto2

  • 1Department of Hepatobiliary and Pancreatic Surgery, NHO Kyushu Cancer Center, Fukuoka, Fukuoka, Japan.

Surgical Case Reports
|December 29, 2025
PubMed
Summary

Sequential chemotherapy, including gemcitabine, cisplatin, and S-1 (GCS) followed by gemcitabine, cisplatin, and durvalumab (GCD), enabled conversion surgery for unresectable perihilar cholangiocarcinoma (PHCC) and achieved pathological complete response (pCR). This approach may expand treatment options for advanced PHCC.

Keywords:
GCD chemotherapyGCS chemotherapyconversion surgerypathological complete responseperihilar cholangiocarcinoma

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