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Burden of comorbidities in people with multiple sclerosis: a population-based study in Catalonia

Toni Mora1

  • 1School of Economics & Social Sciences, Universitat Internacional de Catalunya, Barcelona, Spain.

Frontiers in Neurology
|December 29, 2025
PubMed

Insights

People with multiple sclerosis (MS) experience a significant burden of comorbidities early in life. This highlights the need for integrated, lifelong care to manage these complex health conditions effectively.

Area of Science:

  • Neurology
  • Epidemiology
  • Public Health

Background:

  • Multiple sclerosis (MS) patients frequently have chronic comorbidities impacting care and prognosis.
  • Limited population-based data exists for MS comorbidities in Europe.

Purpose of the Study:

  • To determine the prevalence of specific comorbidities in individuals with MS in Catalonia, Spain.
  • Utilize administrative health records for comprehensive comorbidity analysis.

Main Methods:

  • Analysis of 9,998 individuals diagnosed with MS between 2013 and 2017.
  • Stratification of comorbidity prevalence by age and sex, comparing with the general population where possible.

Main Results:

  • MS patients exhibited higher rates of psychiatric, metabolic, and autoimmune comorbidities across all age groups.
  • Young women (18-40) showed increased depression, anxiety, thyroid disease, and migraine.
  • Middle-aged men (50-60) had higher rates of hypertension, hyperlipidemia, and diabetes.

Conclusions:

  • Multiple sclerosis is linked to a considerable early-onset comorbidity burden.
  • Emphasizes the necessity of integrated, multidisciplinary care throughout the lifespan for MS patients.
Abstract

Keywords:
administrative datacomorbidityepidemiologymultiple sclerosispopulation-based studiessex characteristics

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