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A Pathological Complete Response After Pembrolizumab for DNA Mismatch Repair-Deficient/Microsatellite

Bernard L Hanekom1,2, Andrew Coveney2

  • 1Faculty of Medicine, University of Western Australia, Perth, AUS.

Cureus
|December 29, 2025
PubMed
Summary

A patient with advanced, metastatic colorectal cancer (CRC) achieved a complete pathological response after neoadjuvant immunotherapy with pembrolizumab. This highlights immunotherapy

Keywords:
colorectal cancer surgerycomplete pathological responsegeneral surgerymismatch repair deficiencypembrolizumab

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Mismatch Repair01:20

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The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...