Related Experiment Video
Updated: Jan 7, 2026
10:19
Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration
Published on: November 10, 2014
26.2K
Amyloid goiter: A Tunisian case series
Rihab Laamouri1,2,3, Ibtissem Ben Nacef1,2,3, Makram Tbini1,4
1University of Tunis El Manar Faculty of Medicine of Tunis, Tunis, Tunis, Tunisia.
F1000Research
|December 29, 2025
Summary
Amyloid goiter (AG) is rare, often presenting as thyroid enlargement with potential compressive symptoms. Surgical thyroidectomy is both diagnostic and therapeutic for this uncommon condition.
Area of Science:
- Endocrinology
- Pathology
Background:
- Amyloidosis involves systemic amyloid chain deposition, with the thyroid being an exceptionally rare site.
- Amyloid goiter (AG) has an estimated prevalence of 0.17%.
Purpose of the Study:
- To present three cases of amyloid goiter (AG).
- To review the diagnostic and therapeutic approaches for AG.
Main Methods:
- Case series of three male patients diagnosed with AG.
- Surgical total thyroidectomy and pathological examination.
- Literature review of PubMed (2019-2024).
Main Results:
- Patients presented with thyroid enlargement; one had compressive signs.
- Thyroid hormone levels were normal in all cases.
- Pathological examination confirmed AG post-thyroidectomy.
Conclusions:
- Amyloid deposition in the thyroid is uncommon and rarely causes dysfunction.
- Thyroid enlargement with compressive signs may necessitate surgery.
- Thyroidectomy serves as a crucial diagnostic and therapeutic intervention for AG.
Related Concept Videos
01:23The Thyroid Gland
6.5K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
6.5K
01:15Myasthenia Gravis: Diagnostic Tests
1.8K
Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
1.8K