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Related Experiment Video

Updated: Jan 7, 2026

Measuring Lactase Enzymatic Activity in the Teaching Lab

Measuring Lactase Enzymatic Activity in the Teaching Lab

Published on: August 6, 2018

Lactylation in digestive system tumors: from mechanisms to therapeutic target.

Jun Wei^1,2,3, Qian Ding⁴, Hongjun Wang¹

¹School of Basic Medical Sciences, Jilin Medical University, Jilin, China.

Frontiers in Oncology

|December 29, 2025

Summary

Lactylation, an epigenetic modification from lactate metabolism, links cell metabolism to gene transcription, driving digestive cancers. Modulating lactylation offers new therapeutic targets for precision medicine in these tumors.

Keywords:

digestive system tumors epigenetic modification lactylation therapeutic target tumor metabolism

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Published on: January 22, 2018

Area of Science:

Epigenetics and Metabolism
Cancer Biology
Molecular Oncology

Background:

Lactylation is a novel epigenetic modification linked to lactate metabolism.
It regulates chromatin accessibility and gene transcription.
Lactylation influences tumor progression and metabolic reprogramming in digestive cancers.

Purpose of the Study:

To review advances in lactylation in digestive system malignancies.
To highlight lactylation's role in epigenetic regulation and metabolic-epigenetic crosstalk.
To discuss potential biomarkers and therapeutic strategies targeting lactylation.

Main Methods:

Comprehensive literature review of lactylation research in digestive cancers.
Analysis of lactylation's impact on oncogenic signaling and metabolic reprogramming.
Exploration of therapeutic targets and pharmacologic strategies.

Main Results:

Lactylation drives tumor progression, immune evasion, and chemoresistance in esophageal, gastric, colorectal, hepatocellular, pancreatic, and gallbladder cancers.
It involves histone and non-histone protein modifications (e.g., H3K9la, H3K18la).
Lactylation presents potential as biomarkers and therapeutic targets.

Conclusions:

Lactylation is a key epigenetic regulator in digestive tumors, offering insights into tumor biology.
Challenges include standardizing detection and validating clinical efficacy.
Targeting lactylation holds promise for precision medicine and immunotherapy in digestive cancers.