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Updated: Jan 7, 2026

Hepatocyte-specific Ablation in Zebrafish to Study Biliary-driven Liver Regeneration
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Metronidazole-Induced Encephalopathy in a Patient With Hepatitis B Cirrhosis During Treatment for Intra-abdominal

Ayaka Takahashi1, Masamichi Kimura1, Koji Nishikawa1

  • 1Hepatology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, JPN.

Cureus
|December 29, 2025
PubMed

Insights

Metronidazole-induced encephalopathy, a reversible neurotoxicity, can occur at lower doses in cirrhosis patients. Early recognition of cerebellar signs and drug withdrawal are crucial for recovery.

Area of Science:

  • Neurology
  • Toxicology
  • Gastroenterology

Background:

  • Metronidazole-induced encephalopathy (MIE) is a rare, reversible neurotoxicity.
  • Cirrhosis may reduce metronidazole clearance, potentially lowering the toxicity threshold.
  • Symmetric dentate nucleus hyperintensities on MRI characterize MIE.
Keywords:
cirrhosisdentate nucleusdiffusion-weighted imagingencephalopathymetronidazole

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