Gender-Associated Variation in Morphometric Analysis of the Corpus Callosum: A Hospital-Based Cross-Sectional Study...

Area of Science:

• Neuroanatomy
• Radiology
• Human Morphology

Background:

• The corpus callosum (CC) is vital for interhemispheric connectivity and cognitive functions.
• Existing literature lacks consensus on CC's gender and age variations, especially in South Asian populations.
• Precise CC morphometry is essential for surgical interventions and understanding neurological conditions.

Purpose of the Study:

• To investigate gender- and age-related variations in corpus callosum (CC) morphology.
• To establish reliable baseline parameters for CC dimensions in a South Asian cohort.
• To inform clinical and research applications requiring accurate CC measurements.

Main Methods:

• Retrospective analysis of 200 brain MRI scans (55% male, 45% female).
• Measurement of various CC morphometric parameters including length, thickness, and regional dimensions.
• Comparison of CC measurements across different age groups and between sexes.

Main Results:

• Females showed greater callosal length and thickness, while males had larger overall brain length.
• Age-related differences were observed, particularly in anterior and posterior CC regions, with significant increases in length and thickness in younger adults.
• Splenial length and callosal height showed significant sex-related variations in specific age groups.

Conclusions:

• Measurable gender and age-related differences in CC morphology exist.
• Findings provide population-specific reference data for anatomical and neuroimaging studies.
• Structural interrelationships among CC segments and overall brain length were highlighted.