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Bone scintigraphy in hereditary multiple exostoses.

D A Epstein, E J Levin

    AJR. American Journal of Roentgenology
    |February 1, 1978
    PubMed
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    Bone scintigraphy can detect renewed growth in multiple hereditary exostoses, aiding in early diagnosis of potential chondrosarcoma. This imaging technique is valuable for monitoring adult patients with this skeletal disorder.

    Area of Science:

    • Orthopedics
    • Nuclear Medicine
    • Skeletal Dysplasias

    Background:

    • Multiple hereditary exostoses (MHE) is a genetic skeletal disorder characterized by the formation of numerous benign bone tumors (exostoses).
    • These exostoses have a recognized potential for malignant transformation, primarily into chondrosarcoma.
    • Effective surveillance strategies are crucial for early detection of malignancy in adult MHE patients.

    Observation:

    • Two adult patients diagnosed with MHE presented with specific exostoses exhibiting renewed growth.
    • Bone scintigraphy using 99mTc diphosphonate revealed increased uptake in these actively growing lesions.
    • Other non-growing exostoses in both patients did not show abnormal radiotracer accumulation.

    Findings:

    • Histological examination of the increased uptake lesions confirmed chondrosarcoma in one patient.

    Related Experiment Videos

  • The second patient's lesion with increased uptake was identified as a benign osteochondroma.
  • Bone scintigraphy indicated active bone remodeling or growth, not specifically malignancy.

    • Implications:

    • Bone scintigraphy serves as a valuable tool for periodic surveillance in adult MHE patients.
    • It can non-specifically identify areas of concern (renewed growth) that warrant further investigation.
    • This imaging modality demonstrates superior utility compared to radiographic bone surveys for MHE surveillance.