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Published on: June 10, 2025
Correlation of NT-proBNP With Duration of Hospital Stay in Patients With Heart Failure: A Retrospective Review
Harshitha Harshitha1, Krishna Prasad Lakshminarayana Hoskere2, Meghana Sreenivas3
1General Medicine, Father Muller Medical College, Mangalore, IND.
Insights
High N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels in heart failure (HF) patients correlate with longer hospital stays and increased mortality. This biomarker aids in early risk assessment and resource allocation for HF care.
Area of Science:
- Cardiology
- Biomarker Research
- Clinical Medicine
Background:
- Heart failure (HF) is a major global health concern, leading to significant hospitalizations and mortality.
- N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a recognized biomarker for HF diagnosis and prognosis.
- The association between NT-proBNP levels and hospital length of stay (LOS) in HF patients requires further investigation.
Purpose of the Study:
- To determine the correlation between NT-proBNP levels and LOS in hospitalized HF patients.
- To identify clinical predictors of in-hospital mortality in this cohort.
Main Methods:
- Retrospective observational study of 45 HF patients admitted between October 2024 and May 2025.
- Collected demographic, clinical, echocardiographic, and laboratory data, including NT-proBNP levels.
- Statistical analysis included Spearman's rank test for correlation and univariate Firth logistic regression with ROC analysis for mortality prediction.
Main Results:
- Mean age was 64.8 years, with 53.3% females. Mean NT-proBNP was 6443 pg/mL and mean LOS was 10.8 days.
- Higher NT-proBNP levels were observed in non-survivors (10977 pg/mL) versus survivors (5607 pg/mL; p=0.027).
- A moderate positive correlation (ρ=0.425, p=0.004) existed between NT-proBNP and LOS. An NT-proBNP cut-off of 8823 pg/mL predicted mortality (AUC=0.76).
Conclusions:
- Elevated admission NT-proBNP levels are significantly associated with prolonged hospital stay and higher in-hospital mortality in HF patients.
- NT-proBNP serves as a valuable biomarker for early risk stratification and prognosis assessment in HF.
- Findings support the use of NT-proBNP for optimizing healthcare resource allocation in HF management.
Background:
Heart failure (HF) is a leading cause of hospitalization and mortality worldwide, and the burden of the disease is increasing on a daily basis. N-terminal pro-B-type natriuretic peptide (NT-proBNP) is an established biomarker for diagnosis and prognosis in HF, but its relationship with length of hospital stay remains underexplored. Understanding this association may help in early risk stratification and optimize healthcare resource utilization.
Objective:
To evaluate the correlation between NT-proBNP levels and length of hospital stay in patients admitted with HF and to identify clinical predictors of in-hospital mortality.
Methods:
This retrospective observational study included 45 patients admitted with HF to Father Muller Medical College Hospital, Mangalore, between October 2024 and May 2025. Demographic, clinical, echocardiographic, and laboratory data, including NT-proBNP levels, were collected from hospital records. Statistical analyses were performed using Jamovi 2.7 and R Studio. Correlations were assessed using Spearman's rank test, and predictors of in-hospital mortality were evaluated with univariate Firth logistic regression and ROC analysis.
Results:
The mean age of participants was 64.8 ± 10.5 years; 53.3% were female. The mean NT-proBNP level was 6443 ± 4953 pg/mL, and the mean hospital stay was 10.8 ± 6.4 days. NT-proBNP levels were significantly higher in non-survivors (10977 ± 5687 pg/mL) than survivors (5607 ± 4396 pg/mL; p = 0.027). A moderate positive correlation was observed between NT-proBNP and hospital stay (ρ = 0.425, p = 0.004). ROC analysis identified an NT-proBNP cut-off of 8823 pg/mL for predicting mortality (AUC = 0.76, sensitivity = 86%, specificity = 79%).
Conclusion:
Elevated NT-proBNP levels at admission are strongly associated with prolonged hospital stay and increased in-hospital mortality among HF patients. NT-proBNP may serve as a valuable biomarker for early risk stratification and assessing prognosis, enabling efficient resource allocation.
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